Analysis of the relationship between type of HPV infection and multiple infection and female cervical lesion

ObjectiveTo analyze the relationship between type of human papilloma virus (HPV) infection and multiple infection and female cervical lesion.

MethodsA total of 6 000 samples for HPV typing and thin-prep cytology test (TCT) were selected for retrospective analysis.First, the samples were screened by TCT, and then the type of HPV infection and multiple infection of the samples were analyzed.The cervical pathological biopsy method was used to determine the cervical lesions of patients, the cervical lesions of patients with different types of HPV infection were analyzed, the cervical lesions of women with single infection and multiple infection were observed, and the relationship between type of HPV infection and multiple infection and female cervical lesion.

ResultsAmong the 6 000 HPV test samples, 1 034 were HPV-positive, with a positive rate of 17.23%.Among the patients with HPV infection, 21 gene subtypes were detected, in which the top three high-risk types were HPV16, HPV52 and HPV56, and the most type of low-risk infection was HPV6.Among HPV-positive patients, 634 cases(61.32%) were with chronic inflammatory diseases, 208 cases (20.12%) with cervical intraepithelial neoplasia(CIN) grade Ⅰ, 128 cases (12.38%) with CIN grade Ⅱ-Ⅲ, and 64 cases (6.18%) with cervical cancer.Logistic regression analysis showed that HPV16 and HPV18 infection were closely associated with cervical cancer(P < 0.01 and P < 0.05).Among HPV-positive patients, 761 cases(73.60%) were single infection and 273 cases(26.40%) were multiple infection.Most of the patients with different grades of cervical lesions were single infection, and with the increase of the severity of the lesions, the proportion of single infection increased significantly, while the proportion of multiple infection decreased(P < 0.01).

ConclusionsAmong the type of HPV infection, HPV16 and HPV18 are the high-risk factors affecting the development rate of female cervical lesions.Multiple infection or not is significantly associated with female cervical lesion.Patients with cervical lesion mainly have HPV single infection.