Correlation analysis of BUN, Cr, UA, β2-MG levels, serum CK-MB, cTnI, NT-probNP levels and chronic hypertension complicated with severe preeclampsia

ObjectiveTo study the correlation between the levels of blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), β2 microbulin (β2-MG) levels, serum creatine kinase isoenzyme (CK-MB), troponin Ⅰ (cTnI), N-terminal brain natriuretic peptide precursor (NT-proBNP) levels and chronic hypertension complicated with severe preeclampsia.

MethodsA total of 360 patients with chronic hypertension were included in the study. According to the complication of severe preeclampsia, 89 cases were divided into group A (complication of severe preeclampsia) and 271 cases were divided into group B (non-complication of severe preeclampsia). In addition, 100 normal pregnant women were selected as group C and 100 patients with preeclampsia were selected as group D. The baseline data of the four groups were compared, and the serum levels of BUN, Cr, UA, β2-MG, CK-MB, cTnI and NT-proBNP were compared. The relationship between severe preeclampsia in chronic hypertension patients and various influencing factors was determined by multivariate logistic regression analysis. In addition, adverse pregnancy outcomes in neonates and pregnant women in the four groups were compared.

ResultsThe age of group A was higher than that of group B, group C, and group D, and the age of group B and group D was higher than that of group C (P < 0.05 to P < 0.01). The proportion of preeclampsia history in group A and group D was higher than that in group B and group C (P < 0.01). The duration of hypertension in group A was higher than that in group B, and the difference was statistically significant (P < 0.01). Serum BUN, Cr, UA, β2-MG, CK-MB, cTnI, and NT-proBNP, as well as the incidence of low birth weight, intrauterine growth retardation, fetal distress, fetal asphyxia, macrosomia, congenital abnormalities, and fetal death in newborns, the overall incidence of adverse pregnancy outcomes in pregnant women, were higher than those in group C, and the above indicators in group A were higher than those in group B and group D (P < 0.05). Multivariate logistic regression analysis found that maternal age, history of preeclampsia, course of hypertension, and serum BUN, Cr, UA β2-MG, CK-MB, cTnI, and NT-proBNP levels were risk factors for severe preeclampsia in patients with chronic hypertension (P < 0.05 to P < 0.01). Pearson correlation analysis found that serum BUN, Cr, UA, β2-MG, CK-MB, cTnI, and NT-proBNP were positively correlated with chronic hypertension complicated with severe preeclampsia (P < 0.01).

ConclusionsThe occurrence of severe preeclampsia can be effectively predicted by detecting serum BUN, Cr, UA, β2-MG, CK-MB, cTnI and NT-proBNP levels in clinical work.