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    LI Wan-qing, CAI Ling-ling, GUO Li-yuan, WANG Ying, LIU Si-han, JI Guang, ZHANG Feng-chuan. Difference of intestinal flora in chloasma patients based on 16S rRNA gene sequencing[J]. Journal of Bengbu Medical University, 2023, 48(6): 762-765. DOI: 10.13898/j.cnki.issn.1000-2200.2023.06.012
    Citation: LI Wan-qing, CAI Ling-ling, GUO Li-yuan, WANG Ying, LIU Si-han, JI Guang, ZHANG Feng-chuan. Difference of intestinal flora in chloasma patients based on 16S rRNA gene sequencing[J]. Journal of Bengbu Medical University, 2023, 48(6): 762-765. DOI: 10.13898/j.cnki.issn.1000-2200.2023.06.012
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    Difference of intestinal flora in chloasma patients based on 16S rRNA gene sequencing

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      • Abstract
    • ObjectiveTo compare the intestinal flora diversity and bacterial phenotypes between chloasma patients and healthy people by a new generation 16S rRNA sequencing technology.
      MethodsThirty patients with chloasma were recruited as study group, while 20 healthy individuals were recruited as control group.Structural composition and phenotypic characteristics of bacterial community were analyzed in stool samples with sequencing.
      ResultsThe abundance and diversity of the intestinal flora community were relatively reduced in the study group.Compared with control group, the abundance of Bacteroidota, Bacteroidia, Bacteroidales, Prevotellaceae, Bacteroidaceae, Prevotella, and Bacteroides were lower, while Firmicutes, Actinobacteriota, Actinobacteria, Lactobacillales, Bifidobacteriales, Lachnospiraceae, and Blautia were higher in study group (P < 0.05 to P < 0.01).
      ConclusionsThe intestinal flora differs between the patients with chloasma and healthy people.
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