ObjectiveTo investigate the value of serum miR-21-3p detection combined with ultrasound-guided lymph core needle biopsy (LCNB) in the diagnosis of cervical lymph node metastasis of thyroid cancer.
MethodsA total of 80 patients with thyroid cancer with cervical lymph node enlargement received serum miR-21-3p detection and LCNB were collected.The histopathologic results were taken as the gold standard to compare the diagnostic value of serum miR-21-3p, ultrasound-guided LCNB and their combination in thyroid cancer with cervical lymph node metastasis.
ResultsThe histopathologic results showed cervical lymph node metastasis in 49 patients and no cervical lymph node metastasis in 31 patients.The accuracy and sensitivity of serum miR-21-3p detection combined with ultrasound-guided LCNB in the diagnosis of thyroid cancer with cervical lymph node metastasis were 91.8% and 87.6%, respectively, which were higher than the accuracy of 76.2%, 84.7% and sensitivity of 82.3% and 85.7% of the two independent examinations (P < 0.05).The area under the receiver operator characteristic curve of the combined examination was 0.907 1, which was higher than that of the two independent examinations (0.776 5 and 0.829 2) (P < 0.05).
ConclusionsCompared with single detection, serum miR-21-3p combined with ultrasound-guided LCNB has better accuracy, sensitivity and diagnostic efficiency in the diagnosis of lymph node metastasis of thyroid cancer.
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