Relationship between cholecystolithiasis complicated with non-alcoholic fatty liver disease and metabolic syndrome

ObjectiveTo explore the relationship between cholecystolithiasis complicated with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS).

MethodsAccording to the principle of sex and age match, we conducted a case-control study with 60 patients with cholecystolithiasis complicated with NAFLD in observation group (1 patient withdrew voluntarily, 59 patients were actually included) and 60 patients with cholecystolithiasis in control group.The general data and related indexes of MS were collected, including waistline, body mass index(BMI), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), fasting blood glucose (FPG), fasting insulin (FINS), insulin resistance (IR), alanine aminotransferase (ALT), alanine aminotransferase (AST), tumour necrosis factor-α(TNF-α), interleukin-6 (IL-6), etc.The differences between two groups were analyzed and multivariate conditions logistic regression analysis was used to screen risk factors.

ResultsThe prevalence of MS in the observation group was higher than that in the control group (P < 0.05).There was significant difference in waist circumference between the observation group and the control group (P < 0.05).The levels of BMI, MS, TG, TC, ALT, FINS, IR, TNF-α and IL-6 in the observation group were significantly higher than those in the control groups (P < 0.05).Multivariate condition logistic regression analysis showed that BMI, TG, ALT, IR, TNF-α, IL-6 were independent risk factors for cholecystolithiasis complicated with NAFLD (P < 0.05).

ConclusionsBMI, TG, ALT, IR, TNF-α, IL-6 are independent risk factors for cholecystolithiasis complicated with NAFLD.Cholecystolithiasis with NAFLD complicated is closely associated with MS.