Diagnostic value of serum NT-proBNP combined with D-dimer in patients with ACS without reflow after emergency PCI

ObjectiveTo investigate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) combined with D-dimer in predicting the occurrence of no-reflow in patients with acute coronary syndrome (ACS) after emergency emergency percutaneous coronary intervention (PCI).

MethodsEighty ACS patients who underwent emergency PCI were selected as the research subjects.Among them, 39 cases had no-reflow after PCI, and 41 had normal reflow.The levels of serum NT-proBNP and D-dimer in the patients were detected before PCI.The ROC curves were used to evaluate the predictive value of NT-proBNP and D-dimer for no-reflow.Logistic regression model was used to analyze the independent influencing factors of no-reflow.

ResultsThe levels of NT-proBNP and D-dimer in patients without reflow were significantly higher than those in patients with normal reflow (P < 0.01 and P < 0.05).Logistic regression analysis showed that diabetes, longer time from emergency room to vascular patency, high levels of D-dimer and NT-proBNP were all independent risk factors of no-reflow (P < 0.05 to P < 0.01).ROC curve analysis showed that the AUC value of NT-proBNP combined with D-dimer was 0.852, and the sensitivity and specificity were 85.6% and 70.9%, respectively.

ConclusionsPreoperative NT-proBNP combined with D-dimer has a certain clinical value in predicting the occurrence of no-reflow after PCI in patients with ACS.