Study on the predictive value of serum levels of LDH, UA and calcium ion in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension

ObjectiveTo explore the predictive value of serum lactate dehydrogenase(LDH), uric acid(UA) and calcium ion levels in the adverse pregnancy outcomes in patients with pregnancy-induced hypertension.

MethodsOne hundred and twenty patients with pregnency-induce hypertension were selected as the observation group, and 120 healthy pregnant women in the same period were selected as the control group.The levels of serum LDH, UA and calcium ion, and incidence rates of adverse outcomes in maternal and perinatal infants were compared between two groups.The levels of serum LDH, UA and calcium ion in patients with poor maternal and perinatal outcomes were compared with those with good outcomes in observation group.Logistic regression model was used to analyze the influencing factors of adverse outcomes of maternal and perinatal infants with pregnency-induce hypertension, and the receiver operating characteristic ROC (curve) was used to analyze the predictive efficacy of the serum LDH, UA and calcium ion levels in maternal and perinatal adverse outcomes of patients with pregnency-induce hypertension.

ResultsThe serum levels of LDH, UA in the observation group were higher than those in control group(P < 0.01), the serum level of calcium ion in the observation group was lower than that in control group(P < 0.01), and the incidence rates of maternal and perinatal adverse outcomes in the observation group were higher than those in control group (P < 0.01).In the observation group, the age and serum levels of serum LDH and UA in patents with poor outcomes of the mother and perinatal infants were higher than those with good outcomes of maternal and perinatal infants(P < 0.05 to P < 0.01), and the level of serum calcium ion was lower than those with good outcomes of maternal and perinatal infants(P < 0.05).The resultts of logistic regression model analysis showed that after adjusting for age, the increase of serum LDH and UA levels and decrease of calcium ion level were the independent risk factors of maternal and perinatal adverse outcomes in patients with pregnency-induce hypertension(P < 0.01), and the predictive sensitivity and area under ROC curve of serum LDH, UA combined with calcium ion levels in maternal and perinatal adverse outcomes of pregnency-induce hypertension patients were higher than those predicted alone(P < 0.05).

ConclusionsThe serum LDH and UA levels increase, and the calcium ion level decreases in patients with pregnancy-induced hypertension.All are the independent influencing factors of adverse pregnancy outcomes, and the combined detection of the three factors is better in predicting adverse pregnancy outcomes.