Analysis of inflammatory factor change in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy

ObjectiveTo analyze the changes of inflammatory factors in the perioperative period and myocardial injury-related factors in patients with coronary heart disease after intervention therapy.

MethodsSixty-five patients with coronary heart disease undergoing percutaneous coronary intervention were selected as the study subjects.According to myocardial injury occurrence or not in the perioperative period after intervention therapy, they were divided into the myocardial injury group and non-myocardial injury group.The general data and the levels of inflammatory factors before and after operation were compared between the two groups.Logistic regression was used to analyze the risk factors for occurrence of postoperative myocardial injury.

ResultsThere was no significant difference in high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10) and interferon-γ (IFN-γ) levels before operation between the two groups (P>0.05).The levels of hs-CRP, TNF-α, IL-10 and IFN-γ in the two groups after operation were higher than those before operation (P < 0.05 to P < 0.01), and the levels of hs-CRP, IL-10 and IFN-γ in myocardial injury group were higher than those in non-myocardial injury group (P < 0.05 to P < 0.01).There were significant differences in apolipoprotein B level, age, history of hypertension, history of diabetes mellitus, history of smoking, type of coronary heart disease, and preoperative loading dose of statins between the two groups (P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that age >60 years old, unstable coronary heart disease type, preoperative loading dose of statins, and apolipoprotein B level were the risk factors for occurrence of postoperative myocardial injury (P < 0.05).

ConclusionsThe increased levels of inflammatory factors in patients with coronary heart disease in the perioperative period after intervention therapy, age >60 years old, unstable coronary heart disease type, and preoperative loading dose of statins are risk factors for occurrence of postoperative myocardial injury.