ObjectiveTo study anxiety and depression in patients with systemic lupus erythematosus (SLE) and its related factors.
MethodsSocial demographic data and disease activity indicators were collected from 202 patients with SLE.Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to evaluate anxiety and depression.Univariate, association rule analysis and logistic regression were used to analyze the related influencing factors of anxiety, depression and anxiety combined with depression.
ResultsAmong 202 patients with SLE, the incidence of depression was 43.56% (88/202), the incidence of anxiety was 47.53% (96/202) and the incidence of anxiety combined with depression was 37.13% (75/202).Univariate analysis showed that the medical insurance type, marital status, annual income, employment status, fertility status and Pittsburgh Sleep Quality Index (PSQI) were related factors in the anxious group (P<0.05 to P<0.01), the medical insurance type, systemic lupus erythematosus disease activity index (SLEDAI) and PSQI were related factors in the depression group (P<0.01), while the disease course, education level, medical insurance type, fertility status, SLEDAI, and PSQI were the related factors in the anxiety combined with depression group (P<0.05 to P<0.01).Logistic regression analysis showed that the SLEDAI, PSQI and medical insurance types were independent risk factors for anxiety combined with depression (P<0.05 to P<0.01), among them, the type of medical insurance was the biggest risk factor (OR=3.720, P<0.01).Association rule analysis showed that the incidence of anxiety and depression was significantly associated with SLEDAI and PSQI in SLE patients.
ConclusionsSLE patients are prone to anxiety and depression, which is closely related to economic status, disease activity and other factors.
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