Study on the correlation between serum MAL protein level and acute coronary syndrome

ObjectiveTo study the relationship between MAL protein and acute coronary syndrome (ACS) and the severity of coronary arteries.

MethodsA total of 122 patients diagnosed as ACS were selected as the study group, and then divided into subgroups: acute myocardial infraction (AMI) group, including 60 patients; unstable angina(UA) group, including 62 patients.Patients who underwent coronary angiography that without markable coronary artery straitness were selected as control group.ELISA was used to evaluate the MAL protein of each group.The clinical significance and difference of MAL protein between groups were evaluated.Gensini score was used to evaluate the relationships between MAL protein and the straitness of acute coronary disease.

ResultsThe level of serum MAL protein in AMI group and UA group was significantly higher than that in control group (P < 0.01), but there was no significant difference between UA group and AMI group (P>0.05).There was no significant correlation between serum MAL protein level and Gensini score in UA group and AMI group (P>0.05).Serum MAL protein level had a certain diagnostic reference value in the diagnosis of ACS.AUC of serum MAL protein for AMI was 0.863, 95%CI was 0.794-0.932, and AUC for UA was 0.768, 95%CI was 0.684-0.852.

ConclusionsSerum MAL protein level in ACS patients is notably higher than that in people with with a normal coronary angiography result.The protein may be useful for the diagnosis of ACS in the future.