Relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke

ObjectiveTo investigate the relationship between early morning blood pressure and neurological function and arterial elasticity in patients with non-disabling acute ischemic stroke.

MethodsA total of 126 patients with acute non-disabling ischemic stroke were selected as the research object, and 100 healthy people who had physical examination during the same period were selected as the control group.Blood pressure, arterial elasticity index and neurological function score were detected and compared between the two groups, and the correlation between early morning blood pressure and arterial elasticity and neurological function was analyzed.

ResultsThe mean systolic blood pressure and mean diastolic blood pressure in the morning in the case group were significantly higher than those in the control group (P < 0.01).The indexes of arterial elasticity, such as carotid radial pulse wave velocity (CrPWV), carotid intima-media thickness (IMT) and stiffness index β were significantly higher than those in the control group (P < 0.01).NIHSS score was also significantly higher than that of the control group (P < 0.01).According to the early morning systolic and diastolic blood pressure levels, the patients in the case group were divided into low-level group, medium-level group and high-level group.The differences of CrPWV, IMT, stiffness index β and NIHSS score of each group were statistically significant (P < 0.01).Correlation analysis showed that early morning blood pressure level was significantly positively correlated with CrPWV, IMT, stiffness index β and NIHSS score (P < 0.01).Multiple linear regression analysis showed that age and early morning systolic blood pressure were the independent influencing factors for CrPWV (P < 0.01 and P < 0.05);LDL-C and early morning systolic blood pressure were the independent influencing factors for IMT (P < 0.01);age, BMI, early morning systolic blood pressure and morning diastolic blood pressure were independent influencing factors for stiffness index β and WIHSS score (P < 0.05 to P < 0.01).

ConclusionsEarly morning blood pressure is related to the degree of neurological impairment and arterial elasticity in patients with non-disabling acute ischemic stroke.