Effect of nutritional intervention on short-term efficacy and adverse reactions in patients with locally advanced esophageal cancer undergoing concurrent chemoradiotherapy

ObjectiveTo explore the impact of nutritional intervention on the short-term efficacy and adverse reactions of locally advanced esophageal cancer patients with nutritional risk undergoing concurrent radiotherapy and chemotherapy.

MethodsPatients with locally advanced esophageal cancer who underwent radical concurrent radiotherapy and chemotherapy were selected, including 45 patients in the observation group who received chemoradiotherapy and active nutritional intervention.The control group (47 cases) only received concurrent chemoradiotherapy without active nutritional intervention.The differences in nutritional status, recent efficacy, and complications of concurrent radiotherapy and chemotherapy between the two groups and the control group were compared.

ResultsForty-four patients in each of the group completed the study.After treatment, the albumin value in the observation group was higher than that in the control group (P < 0.01).The short-term efficacy of the observation group was better than that of the control group, and there was a statistically significant difference in the incidence of postoperative malnutrition between the radiation sensitive group and the radiation insensitive group (P < 0.01).The incidence of grade Ⅲ bone marrow suppression and ≥ grade 2 radiation esophagitis in the control group were lower than those in the control group (P < 0.05 to P < 0.01).After treatment, the rate of ≥ Ⅲ degree bone marrow suppression in the malnutrition group was higher than that in the normal nutrition group (P < 0.01).

ConclusionsNutritional intervention may be an important measure to improve the short-term efficacy and reduce the incidence of adverse reactions in locally advanced esophageal cancer patients with nutritional risk.