ObjectiveTo investigate the changes of macular blood flow density and macular morphological structure after Conbercept combined with subthreshold laser treatment of diabetic macular edema (DME).
MethodsA total of 60 DME patients (60 eyes) were randomly divided into control group and observation group, with 30 cases in each group.The observation group was given glass intravitreal injection of Conbercept combined with retinal subthreshold laser treatment, on the second day after laser therapy, Conbercept was injected into the vitreous cavity once a month for 3 consecutive months.The control group was given glass intravitreal injection of Conbercept, and the injection frequency and interval were the same as those of the observation group.The changes of blood flow density of superficial capillary plexus (SCP) and deep capillary plexus (DCP), central macular thickness (CMT) and best corrected visual acuity (BCVA) before and after treatment were analyzed.
ResultsBefore and after treatment, there was no statistically significant difference in SCP blood flow density between the two groups of patients and at different time points (P>0.05);the difference in DCP blood flow density between the two groups of patients at different time points was statistically significant (P < 0.01).The DCP blood flow density of the two groups of patients increased with time at 1, 2, and 3 months after surgery (P < 0.05), but the degree of increase in the observation group was higher than that in the control group (P < 0.01).Before and after treatment, there were statistically significant differences in CMT and BCVA between the two groups of patients at different time points (P < 0.01);CMT and BCVA in both groups showed a decreasing trend with time at 1, 2, and 3 months after surgery (P < 0.01), and the degree of reduction in the observation group was higher than that in the control group (P < 0.01).
ConclusionsConbercept combined with subthreshold laser and intravitreal injection of Conbercept can reduce macular edema, improve deep vascular blood flow density, and improve visual function in DME patients.However, the short-term effect of Conbercept combined with subthreshold laser treatment of DME is more significant.
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