Expression and clinical significance of CDC20 gene in bladder cancer based on bioinformatics database

ObjectiveTo investigate the expression of CDC20 gene in bladder cancer and its clinical prognostic significance.

MethodsThe expression level of CDC20 gene in bladder cancer was analyzed using Oncomine database and GEPIA database.Kaplan-Meier Plotter was used to analyze the relationship between the expression level of CDC20 and overall survival of bladder cancer patients, LinkedOmics database was applied to analyze the correlation between CDC20 gene expression and age, clinicopathological characteristics of bladder cancer patients, and the CDC20-related protein network map was drawn by STRING database to analyze the physiological process of protein enrichment.

ResultsThe expression level of CDC20 gene in bladder cancer tissue was significantly higher than that in normal bladder tissue(P < 0.01).Kaplan-Meier survival analysis showed that the overall survival of bladder cancer patients with high CDC20 expression was lower than that of bladder cancer patients with low CDC20 expression(P < 0.05).STRING database analysis showed that CDC20-related proteins included FBXO5, CCNB1, AURKA, and so on, which were mainly enriched in physiological processes including cell cycle, oocyte meiosis, progesterone-mediated oocyte maturation, ubiquitin-mediated proteolysis, and so on.LinkedOmics database analysis showed that the expression of CDC20 was correlated with patients' age and race(P < 0.05 and P < 0.01), but was not significantly correlated with TNM stage and pathological stage(P>0.05).

ConclusionsCDC20 gene is overexpressed in bladder cancer and negatively correlated with the prognosis of bladder cancer patients.