Correlation analysis of hepatic blood flow ultrasonic parameters and liver function indexes in primary biliary cholangitis

ObjectiveTo analyze the correlation between hepatic blood flow ultrasonic parameters and liver function indexes in patients with primary biliary cholangitis (PBC).

MethodsA total of 80 patients with PBC (PBC group) treated and 30 patients in the normal physical examination (control group).Ultrasonic blood flow examination and liver function test were examined in all patients, and the corresponding correlation between blood flow parameters and liver function indicators was further analyzed.

ResultsThe levels of serum AST, ALP, γ-GGT and GLO in the PBC group were higher than those in the control group (P < 0.05), and ALB and CHE were lower than those in the control group (P < 0.05).The hepatic vein parameters PVs and PVd in the PBC group were significantly higher than those in the control group (P < 0.05), while the hepatic artery parameters PSV and EDV were lower than those in the control group (P < 0.05), and there were no statistical significance in s/d and RI in PBC group (P>0.05).There were statistically significant differences in age, sex, PSV, EDV, and AST, γ-GGT, ALB and CHE among patients with PBC at different stages (P < 0.05), while there were no statistically significant differences in PVs, PVd, s/d, HARI, ALP and GLO (P>0.05).The age of patients in stage Ⅳ was higher than that in other stages (P < 0.05), and the PSV and EDV in stage Ⅲ were higher than those in stage Ⅰ and stage Ⅳ (P < 0.05).AST was positively correlated with PVs, PVd, PSV and EDV in PBC patients (P < 0.05), while HARI was negatively correlated with γ-GGT (P < 0.05).

ConclusionsHepatic blood flow ultrasound parameters of PBC patients are correlated with liver function indexes, which can provide a reference basis for the clinical evaluation of PBC disease progression.