ObjectiveTo explore the effect of sodium hyaluronate acupoint injection combined with arthroscopic debridement on joint function and serum indexes in treatment for knee osteoarthritis (KOA).
MethodsA total of 120 KOA patients were divided into observation group and control group according to the random number table method, with 60 cases in each group.The control group was treated with arthroscopic debridement, and the observation group was combined with acupoint injection of sodium hyaluronate on the basis of the control group.The dysfunction, joint pain and stiffness scores, excellent and good rate of joint function, serum basic fibroblast growth factor (bFGF), angiopoietin 1(Ang-1), Ang-2 before and after treatment, and adverse reactions were compared between the two groups.
ResultsAfter treatment, the scores of dysfunction, joint pain and stiffness, serum bFGF, Ang-1 and Ang-2 in the two groups were lower than before treatment (P < 0.05), while which in the observation group were lower than those in the control group (P < 0.01).The excellent and good rate of joint function in the observation group was 91.67%, which was higher than 78.33% in the control group (P < 0.05).In the two group, no adverse reactions such as infection, allergies, and severe local pain during injection were found within 3 months after the operation.
ConclusionsSodium hyaluronate acupoint injection combined with arthroscopic debridement in treatment for KOA can effectively improve the joint function and clinical symptoms of patients, and down-regulate serum bFGF, Ang-1 and Ang-2, which is a safe and effective treatment plan.
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