Effects of sevoflurane and desflurane on surgical pleth index in laparoscopic cholecystectomy

ObjectiveTo explore the effect of sevoflurane and desflurane with the same minimum alveolar concentration (MAC) on the surgical pleth index(SPI) during laparoscopic cholecystectomy.

MethodsA total of 90 patients scheduled for laparoscopic cholecystectomy were admitted, and randomly divided into sevoflurane (group S) and desflurane group (group D), with 45 patients in each group.Group S was induced by intravenous infusion of propofol effect chamber concentration of 3 μg/mL + remifentanil effect chamber concentration of 3 ng/mL, inhalation of sevoflurane and intravenous injection of 0.6 mg/kg rocuronium.Group D was induced by intravenous infusion of propofol effect chamber concentration of 3 μg/mL + remifentanil effect chamber concentration of 3 ng/mL, inhalation of desflurane and intravenous injection of 0.6 mg/kg rocuronium.Anesthesia maintenance was performed by continuous inhalation of 1.0 MAC sevoflurane or desflurane, combined with intravenous infusion of remifentanil at an effect chamber concentration of 3 ng/mL.The depth of anesthesia sedation and analgesia was monitored.Heart rate (HR), mean arterial pressure (MAP), bispectral index (BIS) and SPI before anesthesia induction and during pneumoperitoneum were compared between the two groups.

ResultsBefore anesthesia induction, there was no statistically significant difference in BIS, SPI, HR, and MAP between the two groups (P > 0.05).During pneumoperitoneum, the SPI, BIS, and MAP in the group D were significantly lower than those in the group S (P < 0.05).

ConclusionsIn laparoscopic cholecystectomy, desflurane with the same MAC can produce lower SPI values compared to sevoflurane, suggesting that desflurane can produce deeper levels of analgesia.