Relationship between changes of serum GDF-15, NT-proBNP, CD40L levels and prognosis in patients with ventricular arrhythmia

ObjectiveTo investigate the relationship between changes of serum growth differentiation factor-15 (GDF-15), N-terminal-B-type natriuretic peptide (NT-proBNP), leukocyte differentiation antigen 40 ligand (CD40L) levels and prognosis in patients with ventricular arrhythmia.

MethodsA total of 180 patients with ventricular arrhythmia were selected as the observation group, and 60 healthy individuals who underwent physical examinations during the same period were selected as the control group.The serum GDF-15, NT-proBNP, CD40L levels were compared between the two groups.The correlation between serum GDF-15, NT-proBNP, CD40L levels and Lown grading were analyzed.The serum GDF-15, NT-proBNP, CD40L levels in patients with different prognosis were compared.The relationship between serum GDF-15, NT-proBNP, CD40L levels and the prognosis of patients with ventricular arrhythmia were analyzed.Receiver operating characteristic (ROC) curve was drawn, and the predictive value of serum GDF-15, NT-proBNP, and CD40L levels in the prognosis of patients with ventricular arrhythmia were evaluated.

ResultsThe serum GDF-15, NT-proBNP and CD40L levels of the observation group were significantly higher than those of the control group (P<0.01).Spearman correlation indicated that there was a positive correlation between serum levels of GDF-15, NT-proBNP, and CD40L in patients with ventricular arrhythmia and Lown grading (P<0.05).The serum GDF-15, NT-proBNP, and CD40L levels in patients with poor prognosis were significantly higher than those of patients with good prognosis (P<0.01).Logistic regression analysis showed that serum levels of GDF-15, NT-proBNP, and CD40L were all influencing factors for the prognosis of patients with ventricular arrhythmia (P<0.05), and the AUC of the predictive value of serum GDF-15, NT-proBNP, and CD40L levels for the prognosis of patients with ventricular arrhythmia were 0.666, 0.767, and 0.777, respectively, and the AUC of all indicators in combination was 0.855.

ConclusionsThe serum levels of GDF-15, NT-proBNP and CD40L in patients with ventricular arrhythmia are significantly increased.Clinical monitoring of their levels can help predict the prognosis and guide the formulation of clinical treatment plans.