Correlation analysis between preoperative serum CA125 level and extrauterine metastasis in patients with uterine serous carcinoma

ObjectiveTo analyze the relationship between preoperative serum cancer antigen 125 (CA125) levels and extrauterine metastasis in patients with uterine serous carcinoma.

MethodsThe clinical data of patients diagnosed with serous uterine carcinoma from January 2015 to December 2021 were retrospectively analyzed to study the correlation between preoperative serum CA125 level and extrauterine metastasis.

ResultsPreoperative serum CA125 levels were related to fallopian tube, ovarian and omentum metastasis (P < 0.05).Patients with CA125 ≥ 41.36 U/mL were more likely to have extrauterine metastasis (AUC=0.797, sensitivity 70.0%, specificity 88.9%, P < 0.01).Multivariate analysis showed that preoperative serum CA125 ≥ 41.36 U/mL was a risk factor for predicting extrauterine metastasis (P < 0.01).Meanwhile, stromal invasion was also significantly associated with extrauterine metastasis (P < 0.05).The 3-year progression-free survival rate was higher in the CA125-positive group than in the negative group, but the difference was not statistically significant (χ²=0.12, P>0.05);the 3-year overall survival rate was higher in the CA125-positive group than in the negative group (χ²=5.60, P < 0.05).

ConclusionsPreoperative serum CA125 ≥ 41.36 U/mL is a reliable index to predict extrauterine metastasis of uterine serous carcinoma.