Analysis of the difference of thoracolumbar vertebral bone mineral density between type 2 diabetes mellitus population and normal population

ObjectiveTo investigate the distribution difference of thoracolumbar vertebral bone mineral density (BMD) between type 2 diabetes mellitus (T2DM) patients and normal population.

MethodsSixty-eight T2DM patients were selected as the observation group, and 96 health examinees at the same period were selected as the control group.BMD of T₁₁-L₄ vertebral body was measured based on quantitative CT.The two groups were divided into different subgroups according to body mass index (BMI), age and sex.The general data of the two groups, incidence of thoracolumbar vertebral osteoporosis (OP) in different age groups, thoracolumbar vertebral BMD in different BMI groups and thoracolumbar vertebral BMD in different sex groups were compared.

ResultsThe BMI and fasting blood glucose of patients in the observation group were higher than those in the control group (P < 0.05 and P < 0.01).The thoracolumbar vertebral BMD of the subjects in the two groups showed a gradual downward trend, and the BMD of the T₁₁-L₄ vertebrae in the observation group was lower than that in the control group (P < 0.05 to P < 0.01).With the increase of age, the incidence of OP in T₁₁-L₂ vertebrae in the two groups increased (P < 0.01).When BMI < 24 kg/m², the thoracolumbar vertebral BMD in the observation group was lower than that in the control group (P < 0.05).In the female group, the thoracolumbar vertebral BMD in the observation group was lower than that in the control group (P < 0.05 to P < 0.01);in the male group, there was no significant difference in thoracolumbar vertebral BMD between the two groups (P>0.05).

ConclusionsWith the increase of age, thoracolumbar vertebral BMD decreases in both T2DM patients and normal population, which is related to sex and BMI, and T2DM patients are more likely to suffer OP.Therefore, T2DM patients should strengthen the relevant examination of vertebral BMD, and take measures to alleviate bone loss and prevent the occurrence of OP as soon as possible.