Efficacy and prognosis of low molecular weight heparin combined with magnesium sulfate for the treatment of early-onset preeclampsia

ObjectiveTo observe the efficacy and prognosis of low molecular weight heparin combined with magnesium sulfate for the treatment of early-onset preeclampsia.

MethodsEighty patients with early-onset preeclampsia were selected and divided into the observation group and control group according to the treatment method, with 40 cases in each group.The observation group was treated with low molecular weight heparin combined with magnesium sulfate, and the control group was treated with magnesium sulfate.The levels of blood pressure, indicators of coagulation function and renal function, and pregnancy outcome were compared between the two groups before and after treatment.

ResultsThere were no significant differences in systolic blood pressure, diastolic blood pressure, urinary nitrogen (BUN) and 24-h urine protein (24-h UP) between the two groups before treatment (P>0.05);after treatment, the levels of systolic blood pressure, diastolic blood pressure, BUN and 24-h UP in the observation group were lower than those before treatment (P < 0.05), and which were lower than those in the control group (P < 0.05 to P < 0.01).There was no significant difference in the level of activated partial thromboplastin time (APTT) between the two groups before treatment (P>0.05), but there were significant differences in prothrombin time (PT) and D-dimer level (P < 0.05 and P < 0.01);after treatment, the levels of APTT, PT and D-dimer in the two groups were lower than those before treatment (P < 0.05), and the level of D-dimer in the observation group was significantly lower than that in the control group (P < 0.01).The gestational week in the observation group was significantly longer than that in the control group (P < 0.01), the neonatal asphyxia rate was lower than that in the control group (P < 0.05), and there was no significant difference in perinatal mortality between the two groups (P>0.05).

ConclusionsLow molecular weight heparin combined with magnesium sulfate for the treatment of early-onset preeclampsia can improve the coagulation function and renal function of the patients, prolong the gestational week, and improve the maternal and infant outcomes, which is worthy of population.