Correlation between the expression levels of miRNA-16, circRNA-100679 and miRNA-124 and severity of depression

ObjectiveTo know the correlation between the expression levels of microRNA(miRNA)-16, circular RNA(circRNA)-100679 and miRNA-124, and severity of depression.

MethodsEighty-one patients diagnosed with depression for the first time and 80 healthy adults at the same time were divided into the observation group and control group, respectively.The relative RNA expression levels of miRNA-16, circRNA-100679 and miRNA-124 were compared between two groups.According to the changes of Hamilton depression scale version 17(HAMD-17), the observation group was subdivided into the A, B and C groups, the relative expression of RNA among three groups was compared, and the correlation of which was analyzed.

ResultsAfter treatment, the relative expression levels of miRNA-16 and circRNA-100679 in the observation group increased compared with those before treatment, while the relative expression levels of miRNA-124 in the observation group decreased compared with that before treatment(P < 0.01), and the differences of which between two groups were statistically significant(P < 0.05).After treatment, the HAMD-17 scores in A, B and C groups decreased, the relative expression levels of miRNA-16 and circRNA-100679 increased, and the relative expression of miRNA-124 decreased compared with those before treatment(P < 0.01).The HAMD-17 scores and relative expression level of miRNA-124 in group A, group B and group C gradually increased in turn(P < 0.01), and the relative expression levels of miRNA-16 and circRNA-100679 in group A, group B and group C gradually decreased in turn(P < 0.01).The relative expression levels of miRNA-124 were positively correlated with the HAMD-17 score(r=0.557, P < 0.05), and the relative expression levels of miRNA-16 and circRNA-100679 were negatively correlated with the HAMD-17 score(r=-0.325, P < 0.01;r=0.453, P < 0.05).

ConclusionsThe relative expression levels of miRNA-16, circRNA-100679 and miRNA-124 are correlated with the severity of depression.Regulating its expression level may provide a new idea for the treatment of depression.