Correlation analysis between the bone mineral density of different positions, FRAX^® predicted value and BMI in postmenopausal women

ObjectiveTo investigate the correlation between bone mineral density(BMD) of different positions, fracture risk calculated by fracture risk assessment tool(FRAX^®) and body mass index(BMI) in postmenopausal women.

MethodsThe demographic information and BMD-related information of 313 postmenopausal women detected by BMD examination in the First Affiliated Hospital of Bengbu Medical University from September 2020 to August 2021 were investigated.The probability of major osteoporotic fractures(including spine, forearm, hip or shoulder) and probability of hip fracture(PHF) over the next 10 years were calculated using the FRAX^® tool.The correlation of predicted values of FRAX^® and BMD with BMI were analyzed, and it was analyzed whether there was a difference between the FRAX^® predicted values of the combined and uncombined femoral neck T value.

ResultsThe BMD of lumbar spine, femoral neck and total hip increased with the increase of BMI(P < 0.01).In combination with the femoral neck T value, the risk of fracture decreased with the increase of BMI(P < 0.01).At the BMI < 28 kg/m² of the predicted value of FRAX^® without the T value of the femoral neck, the fracture risk decreased gradually with the increase of BMI(P < 0.05), and the fracture risk began to increase at BMI≥28 kg/m².Among people with reduced bone mass, it was difficult to screen out those at high risk of fracture, and the FRAX^® significantly underestimated the risk of major osteoporotic fractures.

ConclusionsThe BMD in people with low body mass is generally low, and the risk of fracture calculated by FRAX^® is relatively high.