Value of high-resolution magnetic resonance imaging parameters with serum MMP9 and hs-CRP to predict the occurrence of acute stroke in patients with middle cerebral artery atherosclerotic stenosis

ObjectiveTo detect the expression levels of serum matrix metalloproteinase-9 (MMP9) and high-sensitivity C reactive protein (hs-CRP) in patients with middle cerebral artery atherosclerotic stenosis and analyze the value of MMP9 and hs-CRP combined with high-resolution magnetic resonance imaging (HRMRI) parameters in predicting the occurrence of acute stroke.

MethodsA total of 183 patients with middle cerebral artery atherosclerotic stenosis were selected and divided into the acute stroke group (89 cases) and non-acute stroke group (94 cases) according to whether acute stroke occurred during hospitalization.Predictive values of stenosis degree, serum MMP9 and hs-CRP levels in patients with middle cerebral artery atherosclerotic stenosis were analyzed.

ResultsVulnerable plaque, degree of stenosis, Essen stroke risk score (ESRS) and levels of MMP9, hs-CRP in the acute stroke group were higher than those in non-acute stroke group (P < 0.05).The area under curve (AUC) of degree of stenosis and the levels of MMP9 and hs-CRP in the predictive of acute stroke in patients with atherosclerotic stenosis were 0.886, 0.857 and 0.634, respectively, and AUC of their combination was 0.923.

ConclusionsSerum MMP9 and hs-CRP combined with HRMRI parameters can greatly improve the accuracy of prediction in acute stroke.