Clinical significance of thrombocytosis in patients with antineutrophil cytoplasmic antibody-associated vasculitis

ObjectiveTo analyze the clinical significance of thrombocytosis in peripheral blood of patients with neutrophil cytoplasmic antibody-associated vasculitis (AAV).

MethodsClinical and relevant laboratory data of 110 AAV patients were analyzed.They were divided into a normal platelet group (n=67) and an increased platelet group (n=43) based on the first peripheral platelet count results after admission.The clinical and relevant experimental examination data of the two groups were compared, and the survival status of the patients was regularly followed up.

ResultsUnivariate analysis found that there were statistically significant differences in gender, age, peripheral white blood cell count, neutrophil count, lymphocyte count, serum complement C3 level, erythrocyte sedimentation rate, and serum C-reactive protein between the two groups (P < 0.05 to P < 0.01).Logistic regression analysis found that gender, peripheral white blood cell count, and neutrophil count were independent risk factors for AAV patients with thrombocytosis (P < 0.05).The usage rate of intensive therapy in the thrombocytopenia group was significantly higher than that in the normal platelet group (P < 0.05).There was a statistically significant difference in mortality rates between the two groups of patients (P < 0.01).

ConclusionsThe condition of AAV patients with increased peripheral platelets is severe and the prognosis is poor, active intervention should be taken to improve the prognosis through early diagnosis and treatment.