Correlation between serum 25-hydroxyvitamin D level and the disease of patients with rheumatoid arthritis complicated with Sjogren′s syndrome and its significance

Objective To investigate the relationship between different levels of 25-hydroxyvitamin D25-(OH)D3 and disease activity, inflammatory factors and other related laboratory indexes in patients with rheumatoid arthritis (RA) complicated with Sjogren′s syndrome (SS), and to explore its clinical significance.

Methods Ninety patients with RA and SS were selected as the study subjects.The 25-(OH)D3 levels in serum were detected by chemiluminescence method and divided into three groups according to the 25-(OH)D3 levels: 38 patients in the deficient group, 33 patients in the insufficient group and 19 patients in the normal group.At the same time, clinical indicators such as the number of joint pain and swelling and related laboratory indicators were collected.Disease activity, such as DAS28 and SDAI, was evaluated.The differences and correlation of related factors among each group were analyzed.

Results The differences in DAS28 and SDAI among patients in 25-(OH)D3 deficiency, insufficiency, and normal groups were statistically significant (P < 0.05 and P < 0.01), and the group with significantly reduced levels of 25-(OH)D3 had significantly higher DAS28 and SDAI (P < 0.05 and P < 0.01).Pearson correlation analysis found a negative correlation between ESR, CRP and 25-(OH)D3 levels in the three groups (P < 0.05).

Conclusions The decreased level of 25-(OH)D3 is correlated with the abnormal increase of ESR and CRP levels in RA patients with SS, and has a certain effect on the activity of RA disease.Regular monitoring of serum 25-(OH)D3 levels in RA patients with SS and timely correction of 25-(OH)D3 deficiency may help promote remission.