Clinical value of serum procalcitonin change rate combined with sIL-2R level in the diagnosis of urinogenic sepsis

Objective To investigate the diagnostic value of serum soluble interleukin-2 receptor (sIL-2R) and procalcitonin change rate in urinogenic sepsis.

Methods A tatol of 78 patients with urinary sepsis were set as the observation group, and 81 patients with general urinary tract infection hospitalized at the same period were set as the control group.The serum procalcitonin level at the time of admission and 72 hours after admission was detected by enzyme-linked fluorescence assay, and the procalcitonin change rate was calculated, the levels of serum sIL-2R and C-reactive protein (CRP) on admission were detected by enzyme-linked immunosorbent assay, the white blood cell count (WBC), neutrophil count and lymphocyte count were detected by automatic blood and body fluid analyzer; the correlation between serum sIL-2R, procalcitonin change rate and routine detection items of urinary tract infection in patients with urinogenic sepsis was analyzed by Pearson correlation; ROC curve was applied to analyze the diagnostic efficacy of serum sIL-2R and procalcitonin change rate for urinogenic sepsis; multivariate logistic regression analysis was used to analyze the factors affecting urinogenic sepsis.

Results The serum levels of sIL-2R, WBC, CRP, and neutrophil count in the observation group were significantly higher than those in the control group, while the change rate of procalcitonin and lymphocyte count were significantly lower than those in the control group (P < 0.01).There was a negative correlation between serum sIL-2R and the change rate of procalcitonin in patients with urinary sepsis (P < 0.01);sIL-2R was negatively correlated with lymphocyte count (P < 0.01), and positively correlated with WBC, CRP, and neutrophil count (P < 0.01).The change rate of procalcitonin was positively correlated with lymphocyte count (P < 0.01), and negatively correlated with WBC, CRP, and neutrophil count (P < 0.01).The area under the curve of sIL-2R and the change rate of procalcitonin alone and in combination for the diagnosis of urinary sepsis were 0.849, 0.851, and 0.908, respectively.The cutoff values of sIL-2R and the change rate of procalcitonin were 43.51 pg/mL and 35.59%, respectively.SIL-2R was an independent risk factor for the occurrence of urinary sepsis, and the rate of changes in procalcitonin was a protective factor for the occurrence of urinary sepsis.

Conclusions The serum sIL-2R level combined with the procalcitonin change rate can be used as an important indicator for the diagnosis of urinogenic sepsis.