Objective To analyze the impacts of intrapartum antibiotic prophylaxis during childbirth on pregnancy outcomes and vaginal flora microecology in patients with genital tract group B Streptococcus (GBS) colonization.
Methods A total of 160 pregnant women for obstetric examination and gave birth were set as the study subjects.All of them had positive GBS examinations.The patients were randomly divided into control group and observation group, 80 cases in each group.Administer antibiotic prophylactic treatment at least 4 hours before delivery in the observation group, the control group was treated with metronidazole suppository before delivery, and the maternal and infant outcomes and vaginal flora microecology in the observation group and the control group were recorded.
Results The total incidence of adverse outcomes in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05).After treatment, the detection rates of GBS, leukocyte esterase, sialidase, acetylglucosaminidase and catalase in the observation group were lower than those in the control group, the detection rates of vaginal flora density Ⅱ-Ⅲ, lactobacillus and cleanliness Ⅰ-Ⅱ was higher than that of the control group (P < 0.05 to P < 0.01).The total effective rate of patients in the observation group was 98.75%, which was higher than that in the control group, which was 83.75%(P < 0.01).
Conclusions Intrapartum antibiotic prophylaxis during childbirth has a good effect on improving pregnancy outcomes in patients with GBS colonization, and can alleviate the microecological environment of vaginal flora, which is worthy of popularization and application in clinical treatment.
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