Study on the correlation of the serum levels of sTREM-1 and hs-CRP with degree of coronary vascular disease and short-term clinical prognosis in patients with acute coronary syndrome

Objective To investigate the correlation of the serum levels of myeloid cell trigger receptor 1(sTREM-1) and hypersensitive C-reactive protein(hs-CRP) with degree of coronary vascular disease and clinical prognosis.

Methods Two hundred patients with coronary angiography were selected, and divided into the unstable angina group(UAP group, 135 cases), acute myocardial infarction group (AMI group, 25 cases) and non-coronary heart disease group(control group, 40 cases) according to their medical history, related examinations and coronary angiography results.The serum levels of sTREM-1 and hs-CRP in all cases were measured, and all patients were followed up for a mean of 6 months to assess the occurrence of major adverse cardiac events(MACE).

Results The serum levels of sTREM-1 and hs-CRP levels in the AMI group and UAP group were significantly higher than those in control group(P < 0.05), and the serum sTREM-1 and hs-CRP levels in triple branches and severe groups(Gensini score >48 points) were significantly higher than those in single, double branches and mild, moderate disease groups(P < 0.05).The serum sTREM-1 and hs-CRP levels in MACE group were higher than those in non-MACE group after 6 months of follow-up(P < 0.05).The results of binary logistic regression analysis showed that the hs-CRP, sTREM-1 and Gensini score were the risk factors of MACE events in ACS patients(P < 0.05).The results of ROC curve showed that the optimal cut-off values of serum sTREM-1 and hs-CRP in predicting the risk of MACE events in ACS patients were 0.33 mg/L and 6.30 mg/L, respectively, and the combination of sTREM-1 and hs-CRP could improve the diagnostic specificity(P < 0.05).

Conclusions Patients with ACS have higher serum sTREM-1 and hs-CRP levels.The serum levels of sTREM-1 and hs-CRP in ACS patients are positively correlated with the number and severity of coronary artery lesions.The serum levels of sTREM-1 and hs-CRP are positively correlated with MACE in ACS patients, and the combination of sTREM-1 and hs-CRP can improve the specificity of MACE event prediction.