Objective To study the relationship between the levels of soluble clusterin-like oxidized low-density lipoprotein receptor-1 (sLox-1) and tissue plasminogen activator inhibitor-1 (tPAI-1) in peripheral blood and adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) for coronary heart disease.
Methods A total of 161 patients with coronary heart disease who were treated by PCI in our hospital were selected as the study group, and 56 healthy volunteers who came to our hospital for physical examination during the same period were selected as the control group.The levels of sLox-1 and tPAI-1 in peripheral blood of the two groups were detected and compared.The patients in the study group were followed up for 12 months.According to whether the patients had MACE during the follow-up period, they were divided into MACE group and non-MACE group.The influencing factors of MACE in patients with coronary heart disease after PCI were analyzed.
Results The levels of peripheral blood sLox-1 and tPAI-1 in the study group were higher than those in the control group (P < 0.01).Univariate analysis showed that the levels of cTnI, hs-CRP, sLox-1, and tPAI-1 in the MACE group were higher than those in the non-MACE group (P < 0.01).Logistic regression analysis showed that the levels of cTnI, hs-CRP, sLox-1, and tPAI-1 were the risk factors for MACE after PCI (P < 0.01).ROC curve analysis showed that the sensitivity, accuracy, and AUC of peripheral blood sLox-1 combined with tPAI-1 levels in predicting MACE in patients with coronary heart disease after PCI were 91.37%, 93.12%, and 0.901, respectively, and higher than peripheral blood sLox-1 and tPAI-1 prediction alone.
Conclusions Peripheral blood sLox-1 and tPAI-1 levels increase in patients with coronary heart disease after PCI, which are risk factors for MACE.Combination of them have high predictive value for the occurrence of MACE of coronary heart disease after PCI.
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