Relationship between SOCS3 gene polymorphism and genetic susceptibility and progression of acute cerebral infarction

Objective To investigate the SOCS3 gene polymorphism of patients with acute cerebral infarction(ACI), and analyze its relationship with disease progression.

Methods According to the National Institute of Health stroke scale (NIHSS) at admission, 310 patients with ACI were divided into the mild group and moderate to severe group. The patients were further divided into the progressive group and non-progressive group according to NIHSS score after 7 days of admission. According to the sequencing results of SOCS3 gene rs8064821, three genotypes of CC, CA and AA were detected, and the distribution difference of each genotype and its predictive value for disease progression were analyzed.

Results The distribution of SOCS3 genotype at rs8064821 in patients with ACI was CC (161 cases), CA (127 cases), and AA (22 cases), and the frequencies were 51.93%, 40.97%, and 7.10%, respectively. Compared with the mild group, the proportion of CC genotype was lower, while the proportion of CA and AA genotypes were higher in moderate to severe group(P < 0.01). Compared with the non-progressive group, the proportion of CC genotype was lower, and the proportion of CA and AA genotype were higher in patients with neurological deficit(P < 0.01).

Conclusions The CA and AA genotypes are the main genotypes of SOCS3 in patients with ACI in northern Anhui of China. The patients with CA and AA are more likely to develop neurological deficits.