Effects of terlipressin on hemodynamics and tissue oxygenation in septic shock

Objective To analyze the effect of terlipressin (TP) on hemodynamics and tissue oxygenation in septic shock.

Methods Seventy patients with septic shock were selected as the study subjects, and divided into control group and observation group according to the random number table method, with 35 cases in each group. The control group was given norepinephrine (NE) treatment, and the observation group was given TP treatment on the basis of the control group. The dosage of NE, hemodynamic indexes, oxygen metabolism indexes, complications, and survival rate within 28 days were compared between the two groups.

Results The dosage of NE in the control group was higher than that of observation group (P < 0.05). There was no significant difference in heart rate (HR) and mean arterial pressure (MAP) between the two groups before treatment (P > 0.05);HR at 6, 12 and 24 h after treatment in the two groups were lower than that before treatment (P < 0.05), and MAP was higher than that in its group before treatment (P < 0.05);HR at 6, 12 and 24 h after treatment in the control group was significantly higher than that in the observation group (P < 0.01), and MAP at 12 and 24 h after treatment in the control group was lower than that in the observation group (P < 0.01 and P < 0.05). There was no significant difference in oxygen saturation (SaO₂), oxygenation index (PaO₂/FiO₂) and blood lactate (Lac) between the two groups before treatment (P > 0.05);SaO₂, PaO₂/FiO₂ at 6, 12 and 24 h after treatment in the two groups were higher than those before treatment (P < 0.05), and Lac was lower than that in its group before treatment (P < 0.05);SaO₂ and PaO₂/FiO₂ at 6, 12 and 24 h after treatment in the control group were lower than those in the observation group (P < 0.05 to P < 0.01), while Lac was higher than that in the observation group (P < 0.05 to P < 0.01). The incidence of complications in the control group was 17.14%(6/35), while that in the observation group was 25.71%(9/35), and the difference of which was not statistically significant (P > 0.05). The survival rate within 28 days in the control group was 68.57%(24/35), while that in the observation group was 62.86%(22/35), and the difference of which was not statistically significant (P > 0.05).

Conclusions TP can significantly reduce the dosage of NE and achieve the goal of resuscitation faster, thus improving the hemodynamics and tissue oxygenation of patients with septic shock.