Clinical value of serum CA125, CA199, CA724 and CEA levels in the diagnosis of peritoneal metastasis of gastric malignant tumors

Objective To investigate the clinical value of single or combined detection of serum carbohydrate antigens CA125, CA199, CA724 and carcinoembryonic antigen(CEA) in the diagnosis of peritoneal metastasis of gastric malignant tumors.

Methods The gastric cancer peritoneal metastasis group(68 cases), gastric cancer non-peritoneal metastasis group(44 cases) and healthy physical examination(control group, 40 cases) were investigated. The serum levels of CA125, CA199, CA724 and CEA were recorded, and the efficacy of serum CA125, CA199, CA724 and CEA in the diagnosis of peritoneal metastasis of gastric malignant tumors were analyzed.

Results The levels of serum CA125, CA199, CA724 and CEA in the control group were lower than those in peritoneal metastasis group and non-peritoneal metastasis group, while the levels of all factors in non-peritoneal metastasis group were lower than those in peritoneal metastasis group, and the differences were statistically significant(P < 0.05 to P < 0.01). The combined positive rates of four items in the peritoneal metastasis group and non-peritoneal metastasis group were 95.83% and 86.36%, respectively, and the difference of which was statistically significant(P < 0.05). In single index detection, the AUC corresponding to CA125, CA199, CA724 and CEA were 0.925, 0.655, 0.782 and 0.801, respectively. Among fours items, CA125 was the highest value and highest diagnostic efficacy. In addition, the sensitivity and specificity of serum CA125 were also high.

Conclusions The combined detection of serum CA125, CA199, CA724 and CEA is of great value in the diagnosis and differential diagnosis of peritoneal metastasis of gastric malignant tumors.