Correlation between the ratio of C reactive protein to albumin and the degree of coronary artery disease in patients with type 2 diabetes mellitus and acute coronary syndrome

Objective To investigate the relationship between the ratio of C reactive protein (CRP) to albumin (ALB) and the severity of coronary artery disease in patients with type 2 diabetes mellitus complicated with acute coronary syndrome.

Methods A total of 90 cases of type 2 diabetes mellitus patients with acute coronary syndrome were selected as the observation group, and 90 cases of type 2 diabetes mellitus patients in the same period were selected as the control group. The clinical data of the two groups were compared, and the influencing factors of the degree of coronary artery disease in type 2 diabetes mellitus patients with acute coronary syndrome were analyzed. Pearson correlation analysis was used to analyze the correlation between CRP/ALB and the degree of coronary artery disease in type 2 diabetes mellitus patients with acute coronary syndrome.

Results The CRP and CRP/ALB levels in the observation group were higher than those in the control group (P < 0.01), while ALB levels were lower than those in the control group (P < 0.01). The results of univariate analysis showed that there were statistically significant differences in CRP, ALB, CRP/ALB, blood glucose control, hypertension, and hyperlipidemia between the moderate to severe groups of patients in the observation group(P < 0.01). Logistic regression analysis showed that CRP, ALB, CRP/ALB, poor blood glucose control, hypertension and hyperlipidemia were risk factors for moderate to severe coronary artery disease in patients with type 2 diabetes mellitus complicated with acute coronary syndrome (P < 0.05). Pearson correlation analysis showed that CRP, CRP/ALB were positively correlated with the severity of coronary artery disease in type 2 diabetes mellitus patients with acute coronary syndrome (P < 0.01), and ALB was negatively correlated with the severity of coronary artery disease in type 2 diabetes mellitus patients with acute coronary syndrome (P < 0.01).

Conclusions CRP/ALB is closely related to the severity of coronary artery disease in patients with type 2 diabetes mellitus complicated with acute coronary syndrome, and it can better reflect the severity of coronary artery disease.