Study on the correlation between plasma Dickkopf-1 and short-term prognosis in patients with acute cerebral infarction with intravenous thrombolysis

Objective: To investigate the relationship between plasma Dickkopf-1 level and short-term prognosis of acute cerebral infarction patients. Methods: The clinical data of 232 patients with acute cerebral infarction treated with intravenous thrombolysis from November 2021 to December 2023 were collected.The patients were divided into the poor prognosis group(97 cases) and good prognosis group(135 cases) according to the mRS Score ≥3 points and 0-2 points at 3 months of onset.The clinical data between two groups were compared.Multivariate logistic regression analysis was used to determine the independent risk factors of clinical outcomes after intravenous thrombolysis. Results: Among 232 patients,the age was (65.91±12.37) years.There were 160 males(68.97%) and 72 females(31.03%).The median baseline NIHSS score was 6 points.There were statistical significances in the age,history of atrial fibrillation,TOAST classification,baseline NIHSS score,PT and plasma Dickkopf-1 level between two groups.The clinical outcomes were taken as the dependent variables,and the age,history of atrial fibrillation,TOAST classification,baseline NIHSS score,PT and plasma Dickkopf-1 level were taken as the independent variables to perform multivariate logistic regression analysis.The results showed that the age,high baseline NIHSS score and plasma Dickkopf-1 level were the independent risk factors of poor short-term prognosis of acute cerebral infarction patients.A nomogram of the prediction model was constructed based on the above variables.The C-index calculated by Bootstrap with 1 000 resamples results was 0.979,and the calibration curve showed that the prediction probability was in good agreement with the actual result. Conclusions: Plasma Dickkopf-1 level can predict the short-term prognosis of acute cerebral infarction.