Study on the relationship between follow-up tCO₂ levels and all-cause death in maintenance hemodialysis patients

Objective: To observe the relationship between the follow-up total carbon dioxide(tCO₂) levels and all-cause death in maintenance hemodialysis(MHD) patients. Methods: The follow-up data of MHD patients were collected,and the cardiovascular and all-cause death were observed. Results: Two hundred and seven patients were observed to the end point of follow-up,with a median follow-up time of 29(15,36) months,and 37 patients had cardiovascular or all-cause death.The results of multivariate COX regression analysis showed that the follow-up tCO₂ level ≤21.80 mmol/L,hypertension,and follow-up serum total calcium level were the independent risk factors of all-cause death in MHD patients(P<0.05 to P<0.01),the all-cause death in MHD patients with follow-up tCO₂ level ≤21.80 mmol/L significantly increased(P<0.01). Conclusions: The follow-up tCO₂ level ≤21.80mmol/L is an independent risk factor of death in MHD patients.Monitoring the follow-up tCO₂ level may predict the occurrence of all-cause death in MHD patients.Improving blood tCO₂ level can reduce all-cause death in MHD patients.