Correlation analysis between changes of NLR and PDW levels and Child-Pugh grading in patients with liver cirrhosis complicated with gastroesophageal variceal bleeding

Objective: To explore the relationship between the of neutrophils to lymphocytes ratio (NLR) and platelet distribution width(PDW) in peripheral blood and Child-Pugh grading in patients with liver cirrhosis complicated with gastroesophageal variceal bleeding(GEVB). Methods: A total of 84 patients with liver cirrhosis complicated with GEVB were selected as the observation group,and 64 healthy people were set as the control group.According to Child-Pugh grading standard,the patients with liver cirrhosis were divided into the A,B and C grades(38 cases in grade A,25 cases in grade B and 21 cases in gradeC,respectively).Patients with liver cirrhosis were divided into the bleeding group(53 cases) and non-bleeding group(31 cases) according to whether they were complicated with variceal bleeding.The NLR and PDW were measured.The Child-Pugh grades A,B and C were compared between the observation group and control group.The differences in the above indicators between the bleeding group and non-bleeding group,and amount of blood lost in the bleeding group were compared. Results: The NLR and PDW in the observation group were higher than those in the control group(P<0.01).The worse the Child-Pugh grade,the higher the NLR,which was positively correlated with Child-Pugh grading(P<0.01).The NLR in the bleeding group was higher than that in non-bleeding group(P<0.01).The greater the amount of bleeding,the higher the NLR (P<0.01).There was no statistical significance between PDW and bleeding(P>0.05). Conclusions: The change of NLR in peripheral blood is related to the Child-Pugh grading in patients with liver cirrhosis complicated with GEVB.The higher the Child-Pugh grading,the higher the NLR level.In clinical work,the degree of patients' illness is predicted according to the level of peripheral blood NLR,which provides a strong basis for prognosis evaluation and clinical treatment of patients.