Study on the correlation between serum levels of Gal-3 and IMA and left ventricular remodeling in patients with dilated cardiomyopathy

Objective: To investigate the relationship between serum levels of galectin-3(Gal-3) and Ischemia modified albumin(IMA) and left ventricular remodeling(LVR) in patients with dilated cardiomyopathy(DCM). Methods: The clinical data of 120 patients with DCM from 2019 to 2023 were retrospectively analyzed.The patients were divided into the observation group(diagnosed with LVR,n=60) and control group(not diagnosed with LVR,n=60) according to whether they were diagnosed with LVR.The levels of serum Gal-3 and IMA were monitored in two groups,and the correlation between these levels and LVR in patients with DCM was analyzed. Results: The levels of serum Gal-3 and IMA in the observation group were higher than those in control group(P<0.01).The results of ROC curve analysis indicated that the AUC of the combined detection of Gal-3 and IMA was 0.909,which was higher than that of the individual detection(0.809 for Gal-3 and 0.854 for IMA).The results of logistic regression analysis showed that the serum Gal-3 and IMA were the independent risk factors of LVR in patients with DCM(P<0.01). Conclusions: The serum Gal-3 and IMA levels are closely related to the occurrence of LVR in patients with DCM.They are important biomarkers for evaluating LVR in patients with DCM,and can provide reference for early clinical intervention.