Diagnostic value of serum STIM1 combined with uterine arterial hemodynamics parameters in hypertensive diseases during pregnancy

Objective: To investigate the expression levels of serum stromal interaction molecule 1(STIM1) and to evaluate the diognostic value of its combination with uterine artery hemodynamic parameters for hypertensive disorders of pregnancy. Methods: One hundred and twelve arterial hemodynamics pregnant women with hypertensive disorders of pregnancy were selected as the observation group,and divided into the gestational hypertension group(48 cases),preeclampsia group(34 cases) and severe preeclampsia group(30 cases) according to the severity of the disease.At the same time,84 pregnant women with normal pregnancy were set as the control group.The serum level of STIM1 was detected by enzyme-linked immunosorbent assay.The flow resistance index(RI),pulsation index(PI),systolic to diastolic velocity ratio(S/D) of uterine artery were measured by ultrasonic diagnostic instrument.The relationship between the serum STIM1 level and hypertensive diseases during pregnancy was analyzed by Pearson correlation analysis.The diagnostic value of serum STIM1 combined with hypertensive diseases during pregnancy in severe preeclampsia were analyzed using ROC curve. Results: Compared with the control group,the serum STIM1 level,RI,PI and S/D values in the cbsenation group significantly increased(P<0.05),and the serum STIM1 level,RI,PI and S/D values significantly increased with the increase of disease severity(P<0.05).The results of Pearson correlation analysis showed that serum STIM1 level was positively correlated with RI,PI and S/D values(r=0.515,0.620,0.592,P<0.05).The results of ROC curve showed that the area under the curve of serum STIM1 combined with artery hemodynamic in the diagnosis of severe preeclampsia was 0.951,which was significantly higher than that of RI,PI,S/D and serum STIM1 alone(P<0.05). Conclusions: The hypertensive diseases during pregnancy RI,PI and S/D of pregnant women with gestational hypertension obviously increase,and the serum STIM1 also obviously increases.The diagnostic value of serum STIM1 combined with hypertensive diseases during pregnancy in severe preeclampsia is higher.