The mechanism of inflammation during acute coronaria syndrome and the anti-inflammation role of fluvastatin

Objective: To observe the mechanism of inflammation during acute coronaria syndrome(ACS) and the anti-inflammation role of fluvastatin.Methods: Seventy-two cases of stable angina pectoris(SAP) were selected as control,and 84 cases of ACS were enrolled in the treatment group which included 39 cases of unstable angina pectoris(UAP),25 cases of non-ST elevated myocardial infarction(NSTEMI) and 20 cases of ST elevated myocardial infarction(STEMI).The treatment group was prescribed fluvastatin 40 mg in addition to the routine therapy.The fluvastatin was taken after supper and the treatment course lasted for 4 weeks.The concentrations of high sensitive C reactive protein(hs-CRP),cholesterol(CHO) and low density lipoprotein(LDL-C) in the blood of the patients were determined before and after treatment separately.Results: Before treatment,the concentration of hs-CRP in ACS group was obviously higher than that in SAP group(P<0.01),while the hs-CRP in STEMI group had no statistic significance compared with that in NSTEMI or UAP groups(P>0.05);the concentrations of CHO and LDL-C in ACS group were not significantly different compared with that in SAP group(P>0.05).After treatment,the concentrations of hs-CRP,CHO and LDL-C in ACS groups were lowered obviously(P<0.01).Conclusions: Inflammation plays an important role in the process of ACS,and fluvastatin possesses the ability of moderating cholesterol and anti-inflammation.