The clinical significance of von willebrand factor antigen detection in patients with acute leukemia

Objective: To explore the clinical meaning of von willebrand factor antigen (vWF:Ag) detection in patients with acute leukemia.Methods: The levels of vWF:Ag,D-dimer and fibrin/fibrinogen degradation products(FDPs) were detected by CA-7000 coagulation analyzer,the levels of lactate dehydrogenase(LDH) and high sensitive C-reactive protein(hs-CRP) were detected by 7600 automated biochemistry analyzer,the complete blood counts were tested by Mindray 6 800 hematology analyzer in 39 patients with acute leukemia(including 15 cases with WBC>50×10⁹ /L and 24 cases with <50×10⁹/L) and 21 normal controls.Results: Compared with the control group,the levels of vWF:Ag,D-dimer,FDPs,LDH and hs-CRP were higher in acute leukemia patients(P<0.01),the levels of vWF:Ag and LDH were higher in acute leukemia patients with WBC>50×10⁹ /L than those with WBC<50×10⁹/L(P<0.05 and P<0.01),vWF:Ag had the positive correlations with D-dimer,FDPs,LDH and hs-CRP.Conclusions: The endothelial cell injury was happened in patients with acute leukemia,which presented as the increase of vWF:Ag,the manifestation was correlated with tumor load,acute phase response and hyperfibrinolysis.