Expression of c-erbB-2,p53,PCNA,ER,PR and Topo Ⅱ in breast cancer and its clinical significances

Objective: To evaluate the clinicopathological significance of expressions of c-erbB-2,p53,proliferating cell nuclear antigen(PCNA),DNA topoisomerase Ⅱ(TopoⅡ),estrogen receptor(ER) and progesterone receptor(PR) in breast cancer.Methods: Eighty-nine cases of paraffin-embedded specimens of breast carcinoma were studied by immunohistochemical technique.Results: The positive rates of c-erbB-2,p53,TopoⅡand PCNA were 64.04%,29.21%,55.06%,and 59.55%,respectively.The expressions of c-erbB-2,PCNA were positively correlated with lymph node metastases(P<0.05),and there was the closely relationship between PCNA and invasive mammary carcinoma.But there was no relationship between TopoⅡ and 1ymph node metastases(P>0.05).Conclusions: The results suggested that c-erbB-2 and PCNA can be effective markers for estimating the prognosis of breast cancer.The expressions of TopoⅡ may be useful in predicting prognosis and leading chemotherapy.