Effect of salvianolate on the platelet aggregation and adhesiveness in healthy volunteers

Objective: To investigate the role of salvianolate in platelet aggregation and adhesiveness in healthy volunteers, and to provide referece to the administered dose of salvianolate. Methods: Twenty-seven healthy volunteers were randomly divided into three groups:200 mg salvianolate group, 300 mg group and 400 mg group. The drug was given by intravenous infusion within one hour and the blood was drawn at intervals. The plasma drug concentration was determined by high performance liquid chroma-togeraphy (HPLC) and the platelet aggregation and adhesiveness rates were assayed simultaneously;the inhibition rates of them were used to evaluate the intensity of pharmacological effects. Results: The inhibition rates of platelet aggregation and adhesiveness of the 3 groups rose gradually after administration of salvianolate, which had obvious time-effect relationship. The concentration reached peaks at 3-5 hour, and the pharmacological effects lagged behind in the 3 groups. Conclusions: Salvianolate may inhibit the aggregation and adhesiveness of platelet.