Change of serum levels of adiponectin and YKL-40 in patients with different coronary heart diseases and its correlation with the severity of coronary artery lesion

Objective: To investigate the change of serum levels of adiponectin and YKL-40 in patients with different coronary heart diseases (CHD),and its relationship with the severity of coronary artery lesion and the stability of atherosclerotic plaque.Methods: Ninety-four patients undergoing coronary angiography were included in the study.According to the opacification results and clinical history,the patients were divided into normal control group,stable angina pectoris (SAP) group,unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group;according to the number of coronary artery stenosis,they were divided into normal control group,single vessel disease group,double vessels disease group and three vessels disease group.Serum levels of adiponectin and YKL-40 were determined and compared among different groups.The degree of coronary artery stenosis was assessed by Gensini score,and the correlation between serum levels of adiponectin,YKL-40 and Gensini score was analyzed.Results: Serum adiponectin concentration in all the groups with CHD was lower than that of controls (P<0.05 to P<0.01).The serum adiponectin concentration in AMI group and UAP group was lower than that of SAP group (P<0.01).No significant difference was found between UAP group and AMI group (P>0.05).Serum YKL-40 concentration in all the groups with CHD was higher than that of controls (P<0.05 to P<0.01).Serum YKL-40 concentration in AMI group and UAP group was higher than that of SAP group (P<0.01).No significant difference was observed between UAP group and AMI group (P>0.05).The serum adiponectin concentration was decreased among normal control group,single vessel disease group,double vessels disease group and three vessels disease group (P<0.05 to P<0.01).The serum YKL-40 concentration was increased among normal control group,single vessel disease group,double vessels disease group and three vessels disease group (P<0.05 to P<0.01).Serum adiponectin concentration was negatively correlated with Gensini score (P<0.01),and serum YKL-40 concentration was positively correlated with Gensini score (P<0.01).Conclusions: The serum levels of adiponectin and YKL-40 are correlated with the degree of coronary artery lesion and instability of atherosclerotic plaque.Patients with serious coronary artery lesion and instable atherosclerotic plaque have a lower serum level of adiponectin and a higher serum level of YKL-40.