Tamsulosin combined with solifenacin for treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy

Objective:To explore the effect of tamsulosin combined with solifenacin for the treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy(ESWL).Methods:Two hundred and seventy patients with distal ureteral calculi were evenly divided into three groups.After ESWL,group A were administered tamsulosin 0.2 mg,group B solifenacin 5 mg and group C solifenacin 5 mg plus tamsulosin 0.2 mg once a day.The expulsion rate and expulsion time of the stone,the recurrence of renal colic,the steinstrasse formation and the side effects during the therapy were compared among the three groups.Results:For the lithiasis 6-10 mm in diameter,there was no significant difference in the stone expulsion rate(P0.05);for the lithiasis 10 mm in diameter,the stone expulsion rate of group C(100.0%) was significantly higher than that of group A(90.5%) and group B(84.8%)(P0.05);the expulsion time of the stone in group C was shorter than group A and B(P0.01),but the pain degree during the stone expulsion in group C was lower than group B(P0.05).The recurrence rate of renal colic and the steinstrasse formation rate had no significant differences among the three groups(P0.05).No severe side effects were observed among the three groups(P0.05).Conclusions:Combination use of tamsulosin and solifenacin is safe and effective for treatment of distal ureteral calculi after extracorporeal shock-wave lithotripsy.It may shorten the stone expulsion time and reduce the steinstrasse formation rate,and is especially suitable for the lithiasis10 mm in diameter.