Detection and clinical significance of serum IL-2, IL-18 and TNF-α in tumor patients before and after chemotherapy

Objective: To investigate the influence of chemotherapy on the immune system.Methods: The serum IL-2,IL-18 and TNF-α in 32 patients with malignant solid tumor were measured by indirect avidin-biotin complex technique and enzyme-linked immunosorbent assay.Results: The experiment showed that the levels of IL-2,IL-18 and TNF-α did not have significant difference before and after chemotherapy one period(P>0.05).Conclusions: The cell-mediated immunity system has strong self-regulated ability when affected by cytotoxic substance in order to maintain its stability and perform its immunity function.