Applications of rocuronium pretreatment in general anesthesia tracheal intubation

Objective: To investigate the effects of rocuronium pretreatment in the patients of general anesthesia tracheal intubation. Methods: Forty-eight ASA Ⅰ-Ⅱ patients undergoing elective surgery under general anesthesia were randomly divided into two groups (24 cases/group):group rocuronium (group R) and group suxamethonium (group S). Intravenous pretreatment of rocuronium 0.06 mg/kg (1/5ED₉₅) was given to group R while the equivalent volume of normal saline to group S. After induction of general anesthesia, rocuronium 0.6 mg/kg (2ED₉₅) and suxamethonium 1.2 mg/kg (4ED₉₅) were injected as a bolus to group R and group S,respectively. The effective time,the onset time,the T₁ Value at one minute and the time of maximal depression of T₁ were observed. At the same time,mean arterial pressure (MAP),heart rate (HR),hood oxygen satu ration (SpO₂) and end tidal carbon dioxide (P_ET CO₂) were observed respectively. Results: There were no significant differences in intubation conditions between the two groups (P>0.05); Furthermore,the largest extent of inhibition is general similar (P>0.05), while the effective time and onset time in group S was significant shorter than that in group R (P<0.01). There was no significant differences in MAP,HR,SpO₂ and P_ETCO₂. Conclusions: In our study,intravenous pretreatment of rocuronium 0.06 mg/kg (1/5ED₉₅) plus 0.6 mg/kg intubation dose of rocuronium is effective and safety.