The relationship of the expression of heparanse and syndecan-1 in glioma tissues to the grades

Objective:To investigate the reltationship between the expression of heparanase and syndecan-1 gene mRNA and the pathological grade in human gliomas. Methods:The realtime polymerase chain reactions was empolyed to detect the expression level of heparanase and syndecan-1 gene mRNA in 40 cases of human gliomas and in 10 cases of benign brain tumors,which was used to evaluate tumor grade. Results:The expression level of heparanase mRNA in gliomas is higher than that in brain tumors(P<0.01),and rising with tumor grade. The expression level of syndecan-1 mRNA in gliomas is significant lower compared to that of benign brain tumors(P<0.01),and decresing with tumor grade. The expression level of heparanase mRNA is reversely correlated to the expression level of syndecan-1 mRNA in human gliomas(P<0.01). Conclusions:The heparanase and syndecan-1 gene expression maybe correlate to the oncogensis and progression of human gliomas,which can provide an effective way to diagnose and treat the human gliomas.