The anti-inflammation and gastrointestinal irritating effect of 2-(E)-(un)substituted benzylidene-5-dimethylamido-cyclopentanone

Objective: To observe the anti-inflammatory and analgesic activities of 2-(E)-(un)substituted benzylidene-5-dimethylamido-cyclopentanone(MB₄) and its irritating effect on gastrointestinal tract.Methods: Local besmear with xylene induced swelling of mice ear and the mice writhing caused by intraperitoneal injection acetic acid,the irritability of gastric mucous membrane by using intragastric administration.Results: MB₄(20mg/kg,40mg/kg) may inhibit the swelling of mice ear induced by xylene(P<0.05 and P<0.01),reduce writhing amount(P<0.01),but its irritating effect on gastrointestinal tract was slighter than that of indomethacin.Conclusions: MB₄ possess anti-inflammation and analgesic actions,but its irritative effects of gastric mucous membrane are small.