Study of the relationship between the Helicobacter pylori and CagA gene in patients with gastric carcinoma

Objective: To investigate the relationship between the expression of Helicobacter pylori(Hp),cytotoxic-associated gene A(CagA) and gastric cancer(GC),as well as the possible mechanism of Hp infection leading to oncogenesis by examining the Hp and CagA of patients with GC and chronic superficial gastritis(CSG).Methods: Hp was examined by rapid urease test,gram stain and serum CagA antibodies.CagA gene of Hp was tested by polymerase chain reaction(PCR).Results: There was no difference in the positive rates of Hp between CSG and GC(45.9% vs 54.8%,P>0.05),but the difference was significant in the positive rates of CagA gene between them (35.3% vs 77.5%,P<0.005).Conclusions: The positive rate of CagA gene in the GC group is significantly higher than that in the CSG group.Hp is correlated to CagA gene and GC.Hp CagA may be involved in the formation of gastric cancer.